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Article

Numb−/low Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling

27 Jul 2017

Abstract excerpt

Abstract Purpose: To elucidate the role and molecular mechanism of Numb in prostate cancer and the functional contribution of Numb−/low prostate cancer cells in castration resistance. Experimental Design: The expression of Numb was assessed using multiple Oncomine datasets and prostate cancer tissues from both humans and mice. The biological effects of the overexpression and knockdown of Numb in human prostate...

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Share to Epigenetics and DNA Methylation
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PMID: 28751447
DOI: 10.1158/1078-0432.ccr-17-0913

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