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The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

23 Nov 2015

Abstract excerpt

The cell fate determinant Numb orchestrates tissue morphogenesis and patterning in developmental systems. In the human mammary gland, Numb is a tumor suppressor and regulates p53 levels. However, whether this function is linked to its role in fate determination remains unclear. Here, by exploiting an ex vivo system, we show that at mitosis of purified mammary stem cells (SCs), Numb ensures the asymmetric outcome...

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PMID: 26598619
DOI: 10.1083/jcb.201505037

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