Article

Numb prevents a complete EMT by modulating Notch signalling

2017-09-02

Abstract excerpt

Epithelial-Mesenchymal Transition (EMT) plays key roles during embryonic development, wound healing, and cancer metastasis. Cells in a partial EMT or hybrid epithelial/mesenchymal (E/M) phenotype tend to exhibit collective cell migration, forming clusters of circulating tumour cells – the primary drivers of metastasis. Activation of cell-cell signalling pathways such as Notch fosters a partial or complete EMT, yet...

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Literature Corpus work: 3c2de0b8-7905-5f3f-9b7f-59650124a058
DOI: 10.1101/183871

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