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Article

Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/β-catenin signaling to T cell factor elements in the Numb promoter.

The Journal of biological chemistry - 21 Jun 2013

Liu Xin-Hua, Wu Yong, Yao Shen, Levine Alice C, Kirschenbaum Alexander, Collier Lauren, Bauman William A, Cardozo Christopher P

Abstract excerpt

Androgen signaling via the androgen receptor is a key pathway that contributes to development, cell fate decisions, and differentiation, including that of myogenic progenitors. Androgens and synthetic steroids have well established anabolic actions on skeletal muscle. Wnt and Notch signaling pathways are also essential to myogenic cell fate decisions during development and tissue repair. However, the interactions...

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Source

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Identifiers

PMID: 23649620
DOI: 10.1074/jbc.M113.478487
PMCID: PMC3689944

Genes

DKK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/β-catenin signaling to T cell factor elements in the Numb promoter.PMID 23649620Read ↗

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