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Article

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling.

Oncotarget - 20 Sept 2016

Zhang Jianchao, Shao Ximing, Sun Haiyan, Liu Ke, Ding Zhihao, Chen Juntao, Fang Lijing, Su Wu, Hong Yang, Li Huashun, Li Hongchang

Abstract excerpt

Triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer with higher rates of early relapse and metastasis, is frequently associated with aberrant activation of epithelial-mesenchymal transition (EMT). Nonetheless, how EMT is initiated and regulated during TNBC progression is not well understood. Here, we report that NUMB is a negative regulator of EMT in both human mammary epithelial cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27506933
DOI: 10.18632/oncotarget.11062
PMCID: PMC5308634

Genes

NUMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling.PMID 27506933Read ↗

Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.Semantic proximity Read ↗

Numb prevents a complete EMT by modulating Notch signallingSemantic proximity Read ↗

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Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitrySemantic proximity Read ↗

Role of NuMA1 in breast cancer stem cells with implications for combination therapy of PIM1 and autophagy inhibition in triple negative breast cancerSemantic proximity Read ↗

A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast CancerSemantic proximity Read ↗

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cellsSemantic proximity Read ↗

NSrp70 suppresses metastasis in triple-negative breast cancer by modulating Numb/TβR1/EMT axisSemantic proximity Read ↗

DNER promotes epithelial–mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancerSemantic proximity Read ↗

The CRL7 <sup>FBXW8</sup> Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB LevelsSemantic proximity Read ↗

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