Article
Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies.
Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2017
Hwang Joyce K, Wang Chong, Du Zhou, Meyers Robin M, Kepler Thomas B, Neuberg Donna, Kwong Peter D, Mascola John R, Joyce M Gordon, Bonsignori Mattia, Haynes Barton F, Yeap Leng-Siew, Alt Frederick W
Abstract excerpt
Variable regions of Ig chains provide the antigen recognition portion of B-cell receptors and derivative antibodies. Ig heavy-chain variable region exons are assembled developmentally from V, D, J gene segments. Each variable region contains three antigen-contacting complementarity-determining regions (CDRs), with CDR1 and CDR2 encoded by the V segment and CDR3 encoded by the V(D)J junction region....
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