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Article

Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.

PLoS computational biology - 1 May 2016

Sheng Zizhang, Schramm Chaim A, Connors Mark, Morris Lynn, Mascola John R, Kwong Peter D, Shapiro Lawrence

Abstract excerpt

Accumulation of somatic mutations in antibody variable regions is critical for antibody affinity maturation, with HIV-1 broadly neutralizing antibodies (bnAbs) generally requiring years to develop. We recently found that the rate at which mutations accumulate decreases over time, but the mechanism governing this slowing is unclear. In this study, we investigated whether natural selection and/or mutability of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Somatic Hypermutation, Immunoglobulin

Source

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Identifiers

PMID: 27191167
DOI: 10.1371/journal.pcbi.1004940
PMCID: PMC4871536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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