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Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing

1 Jan 2012

Abstract excerpt

Our understanding of how antibodies are generated and function could help develop effective vaccines and antibody-based therapeutics against viruses such as HIV-1, SARS coronavirus (SARS CoV), and Hendra and Nipah viruses (henipaviruses). Although broadly neutralizing antibodies (bnAbs) against the HIV-1 were observed in patients, elicitation of such bnAbs remains a major challenge when compared to other viral...

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PMID: 22876240
DOI: 10.3389/fmicb.2012.00277

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