Article
Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis.
BMC medical genetics - 18 Jul 2017
Winbo Annika, Stattin Eva-Lena, Westin Ida Maria, Norberg Anna, Persson Johan, Jensen Steen M, Rydberg Annika
Abstract excerpt
BACKGROUND: Sequence variants in the NOS1AP gene have repeatedly been reported to influence QTc, albeit with moderate effect sizes. In the long QT syndrome (LQTS), this may contribute to the substantial QTc variance seen among carriers of identical pathogenic sequence variants. Here we assess three non-coding NOS1AP sequence variants, chosen for their previously reported strong association with QTc in normal and...
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