Article
Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2.
Circulation. Cardiovascular genetics - 1 Jun 2015
Kolder Iris C R M, Tanck Michael W T, Postema Pieter G, Barc Julien, Sinner Moritz F, Zumhagen Sven, Husemann Anja, Stallmeyer Birgit, Koopmann Tamara T, Hofman Nynke, Pfeufer Arne, Lichtner Peter, Meitinger Thomas, Beckmann Britt M, Myerburg Robert J, Bishopric Nanette H, Roden Dan M, Kääb Stefan, Wilde Arthur A M, Schott Jean-Jacques, Schulze-Bahr Eric, Bezzina Connie R
Abstract excerpt
BACKGROUND: Considerable interest exists in the identification of genetic modifiers of disease severity in the long-QT syndrome (LQTS) as their identification may contribute to refinement of risk stratification. METHODS AND RESULTS: We searched for single-nucleotide polymorphisms (SNPs) that modulate the corrected QT (QTc)-interval and the occurrence of cardiac events in 639 patients harboring different mutations...
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