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Article

NOS1AP is a genetic modifier of the long-QT syndrome.

Circulation - 27 Oct 2009

Crotti Lia, Monti Maria Cristina, Insolia Roberto, Peljto Anna, Goosen Althea, Brink Paul A, Greenberg David A, Schwartz Peter J, George Alfred L

Abstract excerpt

BACKGROUND: In congenital long-QT syndrome (LQTS), a genetically heterogeneous disorder that predisposes to sudden cardiac death, genetic factors other than the primary mutation may modify the probability of life-threatening events. Recent evidence indicates that common variants in NOS1AP are associated with the QT-interval duration in the general population. METHODS AND RESULTS: We tested the hypothesis that...

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Share to Adaptor Proteins, Signal Transducing
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19822806
DOI: 10.1161/CIRCULATIONAHA.109.879643
PMCID: PMC2783481

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOS1AP is a genetic modifier of the long-QT syndrome.PMID 19822806Read ↗

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.Semantic proximity Read ↗

Single nucleotide polymorphisms in arrhythmia genes modify the risk of cardiac events and sudden death in long QT syndrome.Semantic proximity Read ↗

Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2.Semantic proximity Read ↗

Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis.Semantic proximity Read ↗

AKAP9 is a genetic modifier of congenital long-QT syndrome type 1.Semantic proximity Read ↗

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.Semantic proximity Read ↗

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.Semantic proximity Read ↗

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.Semantic proximity Read ↗

Common candidate gene variants are associated with QT interval duration in the general population.Semantic proximity Read ↗

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.Semantic proximity Read ↗

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome.Semantic proximity Read ↗

The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: toward a mutation-specific risk stratification.Semantic proximity Read ↗

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