Article
NOS1AP Polymorphisms Modify QTc Interval Duration But Not Cardiac Arrest Risk in Hypertrophic Cardiomyopathy.
Journal of cardiovascular electrophysiology - 1 Dec 2015
Earle Nikki, Ingles Jodie, Bagnall Richard D, Gray Belinda, Crawford Jackie, Smith Warren, Shelling Andrew N, Love Donald R, Semsarian Chris, Skinner Jonathan R
Abstract excerpt
INTRODUCTION: The accurate prediction of the risk of sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remains elusive. Corrected QT interval (QTc) duration is a known risk factor in various cardiac conditions. Single nucleotide polymorphisms (SNPs) have been linked to QTc length, and to SCD. Here we investigated the role of 21 candidate SNPs in QTc duration and SCD events in patients with HCM....
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