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Article

Single nucleotide polymorphisms in arrhythmia genes modify the risk of cardiac events and sudden death in long QT syndrome.

Heart rhythm - 1 Jan 2014

Earle Nikki, Yeo Han Dug, Pilbrow Anna, Crawford Jackie, Smith Warren, Shelling Andrew N, Cameron Vicky, Love Donald R, Skinner Jonathan R

Abstract excerpt

BACKGROUND: Disease-modifying single nucleotide polymorphisms (SNPs) can help explain incomplete penetrance and variable expressivity in congenital long QT syndrome (LQTS) by altering susceptibility to arrhythmias. OBJECTIVE: The purpose of this study was to assess multiple arrhythmia SNPs (in 16 genes) in a distinct cohort of LQTS patients to identify modifier SNPs influencing the risk of sudden death. METHODS:...

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Source

Identifiers

PMID: 24096169
DOI: 10.1016/j.hrthm.2013.10.005

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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