Article
Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death.
Journal of the American Heart Association - 3 Dec 2019
Mitchell Rebecca N, Ashar Foram N, Jarvelin Marjo-Riitta, Froguel Philippe, Sotoodehnia Nona, Brody Jennifer A, Sebert Sylvain, Huikuri Heikki, Rioux John, Goyette Philippe, Newcomb Charles E, Junttila M Juhani, Arking Dan E
Abstract excerpt
Background Sudden cardiac death (SCD) accounts for ≈300 000 deaths annually in the United States. Men have a higher risk of SCD and are more likely to have underlying coronary artery disease, while women are more likely to have arrhythmic events in the setting of inherited or acquired QT prolongation. Moreover, there is evidence of sex differences in the genetics of QT interval duration. Using sex- and coronary...
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