Article
Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.
Human molecular genetics - 15 Jan 2009
Eijgelsheim Mark, Aarnoudse Adrianus L H J, Rivadeneira Fernando, Kors Jan A, Witteman Jacqueline C M, Hofman Albert, van Duijn Cornelia M, Uitterlinden André G, Stricker Bruno H C
Abstract excerpt
QT-interval prolongation is an electrophysiologic phenomenon associated with sudden cardiac death. The QT-interval in the general population is approximately 35% heritable. In genome-wide association studies, a common variant (rs10494366T > G) within the nitric oxide synthase 1 adaptor protein (NOS1AP) gene was identified and consistently associated with QT-interval duration. Yet, the causal variant remains...
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