Article
Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.
The pharmacogenomics journal - 1 Apr 2018
Seyerle A A, Sitlani C M, Noordam R, Gogarten S M, Li J, Li X, Evans D S, Sun F, Laaksonen M A, Isaacs A, Kristiansson K, Highland H M, Stewart J D, Harris T B, Trompet S, Bis J C, Peloso G M, Brody J A, Broer L, Busch E L, Duan Q, Stilp A M, O'Donnell C J, Macfarlane P W, Floyd J S, Kors J A, Lin H J, Li-Gao R, Sofer T, Méndez-Giráldez R, Cummings S R, Heckbert S R, Hofman A, Ford I, Li Y, Launer L J, Porthan K, Newton-Cheh C, Napier M D, Kerr K F, Reiner A P, Rice K M, Roach J, Buckley B M, Soliman E Z, de Mutsert R, Sotoodehnia N, Uitterlinden A G, North K E, Lee C R, Gudnason V, Stürmer T, Rosendaal F R, Taylor K D, Wiggins K L, Wilson J G, Chen Y-Di, Kaplan R C, Wilhelmsen K, Cupples L A, Salomaa V, van Duijn C, Jukema J W, Liu Y, Mook-Kanamori D O, Lange L A, Vasan R S, Smith A V, Stricker B H, Laurie C C, Rotter J I, Whitsel E A, Psaty B M, Avery C L
Abstract excerpt
Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide polymorphisms (SNPs) modified the association between thiazide use and QT or its component parts (QRS interval, JT interval) by performing ancestry-specific, trans-ethnic and cross-phenotype...
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