Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies.

doi:10.1002/cpt.2355

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Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies.

Clinical pharmacology and therapeutics - 1 Sept 2021

McDonough Caitrin W, Warren Helen R, Jack John R, Motsinger-Reif Alison A, Armstrong Nicole D, Bis Joshua C, House John S, Singh Sonal, El Rouby Nihal M, Gong Yan, Mychaleckyj Joesyf C, Rotroff Daniel M, Benavente Oscar R, Caulfield Mark J, Doria Alessandrio, Pepine Carl J, Psaty Bruce M, Glorioso Valeria, Glorioso Nicola, Hiltunen Timo P, Kontula Kimmo K, Arnett Donna K, Buse John B, Irvin Marguerite R, Johnson Julie A, Munroe Patricia B, Wagner Michael J, Cooper-DeHoff Rhonda M

Abstract excerpt

We sought to identify genome-wide variants influencing antihypertensive drug response and adverse cardiovascular outcomes, utilizing data from four randomized controlled trials in the International Consortium for Antihypertensive Pharmacogenomics Studies (ICAPS). Genome-wide antihypertensive drug-single nucleotide polymorphism (SNP) interaction tests for four drug classes (β-blockers, n = 9,195; calcium channel...

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Identifiers

PMID: 34231218
DOI: 10.1002/cpt.2355
PMCID: PMC8672325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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