Article
Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.
The pharmacogenomics journal - 1 Jun 2020
de las Fuentes Lisa, Sung Y J, Sitlani C M, Avery C L, Bartz T M, Keyser C de, Evans D S, Li X, Musani S K, Ruiter R, Smith A V, Sun F, Trompet S, Xu H, Arnett D K, Bis J C, Broeckel U, Busch E L, Chen Y-D I, Correa A, Cummings S R, Floyd J S, Ford I, Guo X, Harris T B, Ikram M A, Lange L, Launer L J, Reiner A P, Schwander K, Smith N L, Sotoodehnia N, Stewart J D, Stott D J, Stürmer T, Taylor K D, Uitterlinden A, Vasan R S, Wiggins K L, Cupples L A, Gudnason V, Heckbert S R, Jukema J W, Liu Y, Psaty B M, Rao D C, Rotter J I, Stricker B, Wilson J G, Whitsel E A
Abstract excerpt
Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses...
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