Article
Evidence of heterogeneity by race/ethnicity in genetic determinants of QT interval.
Epidemiology (Cambridge, Mass.) - 1 Nov 2014
Seyerle Amanda A, Young Alicia M, Jeff Janina M, Melton Phillip E, Jorgensen Neal W, Lin Yi, Carty Cara L, Deelman Ewa, Heckbert Susan R, Hindorff Lucia A, Jackson Rebecca D, Martin Lisa W, Okin Peter M, Perez Marco V, Psaty Bruce M, Soliman Elsayed Z, Whitsel Eric A, North Kari E, Laston Sandra, Kooperberg Charles, Avery Christy L
Abstract excerpt
BACKGROUND: QT interval (QT) prolongation is an established risk factor for ventricular tachyarrhythmia and sudden cardiac death. Previous genome-wide association studies in populations of the European descent have identified multiple genetic loci that influence QT, but few have examined these loci in ethnically diverse populations. METHODS: Here, we examine the direction, magnitude, and precision of effect sizes...
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