Article
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
The pharmacogenomics journal - 1 Feb 2014
Avery C L, Sitlani C M, Arking D E, Arnett D K, Bis J C, Boerwinkle E, Buckley B M, Ida Chen Y-D, de Craen A J M, Eijgelsheim M, Enquobahrie D, Evans D S, Ford I, Garcia M E, Gudnason V, Harris T B, Heckbert S R, Hochner H, Hofman A, Hsueh W-C, Isaacs A, Jukema J W, Knekt P, Kors J A, Krijthe B P, Kristiansson K, Laaksonen M, Liu Y, Li X, Macfarlane P W, Newton-Cheh C, Nieminen M S, Oostra B A, Peloso G M, Porthan K, Rice K, Rivadeneira F F, Rotter J I, Salomaa V, Sattar N, Siscovick D S, Slagboom P E, Smith A V, Sotoodehnia N, Stott D J, Stricker B H, Stürmer T, Trompet S, Uitterlinden A G, van Duijn C, Westendorp R G J, Witteman J C, Whitsel E A, Psaty B M
Abstract excerpt
Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the 'missing heritability' of complex traits. Here, we describe four independent analyses in 33 781 participants of European ancestry from 10 cohorts that were designed to identify genetic variants modifying the effects of drugs on QT interval duration (QT). Each analysis...
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