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Article

IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza.

The Journal of infectious diseases - 1 Jul 2017

Lee Nelson, Cao Bin, Ke Changwen, Lu Hongzhou, Hu Yunwen, Tam Claudia Ha Ting, Ma Ronald Ching Wan, Guan Dawei, Zhu Zhaoqin, Li Hui, Lin Mulei, Wong Rity Y K, Yung Irene M H, Hung Tin-Nok, Kwok Kirsty, Horby Peter, Hui David Shu Cheong, Chan Martin Chi Wai, Chan Paul Kay Sheung

Abstract excerpt

Background: We examined associations between single-nucleotide polymorphisms (SNPs) of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese. Methods: A multicenter study was conducted on 275 adult cases of avian (H7N9) and pandemic (H1N1pdm09) influenza. Host DNA was extracted from diagnostic respiratory samples; IFITM3 rs12252, TLR3 rs5743313, CD55 rs2564978, and TLR4 rs4986790/4986791 were...

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Share to CD55 Antigens
Share to Genotyping Techniques
Share to Influenza A Virus, H1N1 Subtype
Share to Influenza A Virus, H7N9 Subtype
Share to Influenza, Human
Share to Proportional Hazards Models
Share to RNA-Binding Proteins
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Identifiers

PMID: 28510725
DOI: 10.1093/infdis/jix235
PMCID: PMC7107409

Genes

IFITM3
TLR3
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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