The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19.

doi:10.1016/j.cyto.2021.155492

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Article

The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19.

Cytokine - 1 Jun 2021

Schönfelder Kristina, Breuckmann Katharina, Elsner Carina, Dittmer Ulf, Fistera David, Herbstreit Frank, Risse Joachim, Schmidt Karsten, Sutharsan Sivagurunathan, Taube Christian, Jöckel Karl-Heinz, Siffert Winfried, Kribben Andreas, Möhlendick Birte

Abstract excerpt

BACKGROUND AND AIMS: The interferon-induced transmembrane protein 3 (IFITM3) plays an important role in the adaptive and innate immune response by inhibiting viral membrane hemifusion between the host and viral cell cytoplasm. Single nucleotide polymorphisms (SNPs) in the gene IFITM3 have been as...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
COVID-19
Female
Genetic Predisposition to Disease
Humans
Male
Membrane Proteins
Middle Aged
Polymorphism, Single Nucleotide
RNA-Binding Proteins
SARS-CoV-2

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Identifiers

PMID: 33711707
DOI: 10.1016/j.cyto.2021.155492
PMCID: PMC7936555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-33711707-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.