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Article

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2.

The Journal of clinical investigation - 1 Nov 2010

Hiby Susan E, Apps Richard, Sharkey Andrew M, Farrell Lydia E, Gardner Lucy, Mulder Arend, Claas Frans H, Walker James J, Redman Christopher W, Redman Christopher C, Morgan Linda, Tower Clare, Regan Lesley, Moore Gudrun E, Carrington Mary, Moffett Ashley

Abstract excerpt

Many common disorders of pregnancy are attributed to insufficient invasion of the uterine lining by trophoblast, fetal cells that are the major cell type of the placenta. Interactions between fetal trophoblast and maternal uterine NK (uNK) cells--specifically interactions between HLA-C molecules expressed by the fetal trophoblast cells and killer Ig-like receptors (KIRs) on the maternal uNK cells--influence...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20972337
DOI: 10.1172/JCI43998
PMCID: PMC2964995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2.PMID 20972337Read ↗

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Killer Ig-Like Receptor Expression in Uterine NK Cells Is Biased toward Recognition of HLA-C and Alters with Gestational AgeSemantic proximity Read ↗

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