Article
KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.
The Journal of experimental medicine - 26 Oct 2009
Graef Thorsten, Moesta Achim K, Norman Paul J, Abi-Rached Laurent, Vago Luca, Older Aguilar Anastazia M, Gleimer Michael, Hammond John A, Guethlein Lisbeth A, Bushnell David A, Robinson Philip J, Parham Peter
Abstract excerpt
Human killer cell immunoglobulin-like receptors (KIRs) are distinguished by expansion of activating KIR2DS, whose ligands and functions remain poorly understood. The oldest, most prevalent KIR2DS is KIR2DS4, which is represented by a variable balance between "full-length" and "deleted" forms. We find that full-length 2DS4 is a human histocompatibility leukocyte antigen (HLA) class I receptor that binds...
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