Article
Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations.
Frontiers in immunology - 1 Jan 2020
Vargas Luciana de Brito, Dourado Renata M, Amorim Leonardo M, Ho Brenda, Calonga-Solís Verónica, Issler Hellen C, Marin Wesley M, Beltrame Marcia H, Petzl-Erler Maria Luiza, Hollenbach Jill A, Augusto Danillo G
Abstract excerpt
Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors (KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands. Interaction of KIR and HLA is implicated in viral infections, autoimmunity, and reproduction and there is growing evidence of the coevolution of these two independently segregating gene families. By leveraging KIR and HLA-C data from...
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