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Article

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells.

Genome medicine - 6 Jul 2017

López Rodríguez Maykel, Kaminska Dorota, Lappalainen Kati, Pihlajamäki Jussi, Kaikkonen Minna U, Laakso Markku

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D. We investigated the regulatory function...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Epigenesis, Genetic

Share to Hepatocyte Nuclear Factor 3-beta

Share to Histone Code

Source

Open in PubMed Open full text

Identifiers

PMID: 28683826
DOI: 10.1186/s13073-017-0453-x
PMCID: PMC5501007

Genes

GCKR
FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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