Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus.

PLoS genetics - 1 Sept 2014

Fogarty Marie P, Cannon Maren E, Vadlamudi Swarooparani, Gaulton Kyle J, Mohlke Karen L

Abstract excerpt

Many of the type 2 diabetes loci identified through genome-wide association studies localize to non-protein-coding intronic and intergenic regions and likely contain variants that regulate gene transcription. The CDC123/CAMK1D type 2 diabetes association signal on chromosome 10 spans an intergenic region between CDC123 and CAMK1D and also overlaps the CDC123 3'UTR. To gain insight into the molecular mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Hepatocyte Nuclear Factor 3-alpha

Share to Hepatocyte Nuclear Factor 3-beta

Share to Hepatocytes

Share to Islets of Langerhans

Share to Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 25211022
DOI: 10.1371/journal.pgen.1004633
PMCID: PMC4161327

Genes

FOXA1
FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus.PMID 25211022Read ↗

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.Semantic proximity Read ↗

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells.Semantic proximity Read ↗

Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus.Semantic proximity Read ↗

Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.Semantic proximity Read ↗

In vitro scan for enhancers at the TCF7L2 locus.Semantic proximity Read ↗

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus.Semantic proximity Read ↗

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.Semantic proximity Read ↗

CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes.Semantic proximity Read ↗

Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility.Semantic proximity Read ↗

Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population.Semantic proximity Read ↗

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility lociSemantic proximity Read ↗

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility lociSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.