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Article

In vitro scan for enhancers at the TCF7L2 locus.

Diabetologia - 1 Jan 2013

Savic D, Park S Y, Bailey K A, Bell G I, Nobrega M A

Abstract excerpt

AIMS/HYPOTHESIS: Recent functional characterisations of genome-wide association study (GWAS) loci suggest that cis-regulatory variation may be a common paradigm for complex disease susceptibility. Several studies point to a similar mechanism at the transcription factor 7-like 2 (TCF7L2) GWAS locus for type 2 diabetes. To address this possibility, we carried out an in vitro scan of this diabetes-associated locus...

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Topics

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Share to Chromatin Assembly and Disassembly
Share to Diabetes Mellitus, Type 2
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Genetic Loci

Share to Insulin-Secreting Cells

Share to Organ Specificity

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23011354
DOI: 10.1007/s00125-012-2730-y
PMCID: PMC3525810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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