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Article

Heterochromatic genome stability requires regulators of histone H3 K9 methylation.

PLoS genetics - 1 Mar 2009

Peng Jamy C, Karpen Gary H

Abstract excerpt

Heterochromatin contains many repetitive DNA elements and few protein-encoding genes, yet it is essential for chromosome organization and inheritance. Here, we show that Drosophila that lack the Su(var)3-9 H3K9 methyltransferase display significantly elevated frequencies of spontaneous DNA damage in heterochromatin, in both somatic and germ-line cells. Accumulated DNA damage in these mutants correlates with...

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Identifiers

PMID: 19325889
DOI: 10.1371/journal.pgen.1000435
PMCID: PMC2654965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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