Article
Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer.
PloS one - 1 Jan 2017
De Marco Carmela, Laudanna Carmelo, Rinaldo Nicola, Oliveira Duarte Mendes, Ravo Maria, Weisz Alessandro, Ceccarelli Michele, Caira Elvira, Rizzuto Antonia, Zoppoli Pietro, Malanga Donatella, Viglietto Giuseppe
Abstract excerpt
Hyperactivation of the phosphatydil-inositol-3' phosphate kinase (PI3K)/AKT pathway is observed in most NSCLCs, promoting proliferation, migration, invasion and resistance to therapy. AKT can be activated through several mechanisms that include loss of the negative regulator PTEN, activating mutations of the catalytic subunit of PI3K (PIK3CA) and/or mutations of AKT1 itself. However, number and identity of...
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