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Article

miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma.

Nature communications - 6 Aug 2014

Lin Chuyong, Liu Aibin, Zhu Jinrong, Zhang Xin, Wu Geyan, Ren Pengli, Wu Jueheng, Li Mengfeng, Li Jun, Song Libing

Abstract excerpt

The strength and duration of phosphoinositide signalling from phosphatidylinositol-3-kinase (PI3K) activation to Akt is tightly balanced by phosphoinositide kinases and phosphatases. However, how phosphatase-mediated negative regulatory effects are concomitantly disrupted in cancers, which commonly exhibit constitutively activated PI3K/Akt signalling, remains undefined. Here we report that miR-508 directly...

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Identifiers

PMID: 25099196
DOI: 10.1038/ncomms5620

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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