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Article

PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics.

Journal of cellular physiology - 1 Sept 2012

Mahajan Kiran, Mahajan Nupam P

Abstract excerpt

AKT/PKB serine threonine kinase, a critical signaling molecule promoting cell growth and survival pathways, is frequently dysregulated in many cancers. Although phosphatidylinositol-3-OH kinase (PI3K), a lipid kinase, is well characterized as a major regulator of AKT activation in response to a v...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22307544
DOI: 10.1002/jcp.24065
PMCID: PMC3358464

Genes

IKBKE
PTK6
TBK1
TNK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22307544-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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