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Emerging Roles for AKT Isoform Preference in Cancer Progression Pathways

30 Apr 2021

Abstract excerpt

The phosphoinositol-3 kinase (PI3K)-AKT pathway is one of the most mutated in human cancers, predominantly associated with the loss of the signaling antagonist, PTEN, and to lesser extents, with gain-of-function mutations in PIK3CA (encoding PI3K-p110α) and AKT1. In addition, most oncogenic driver pathways activate PI3K/AKT signaling. Nonetheless, drugs targeting PI3K or AKT have fared poorly against solid tumors...

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PMID: 33931488
DOI: 10.1158/1541-7786.mcr-20-1066

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