AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

doi:10.1016/j.ccr.2009.04.012

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Article

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

Cancer cell - 7 Jul 2009

Vasudevan Krishna M, Barbie David A, Davies Michael A, Rabinovsky Rosalia, McNear Chontelle J, Kim Jessica J, Hennessy Bryan T, Tseng Hsiuyi, Pochanard Panisa, Kim So Young, Dunn Ian F, Schinzel Anna C, Sandy Peter, Hoersch Sebastian, Sheng Qing, Gupta Piyush B, Boehm Jesse S, Reiling Jan H, Silver Serena, Lu Yiling, Stemke-Hale Katherine, Dutta Bhaskar, Joy Corwin, Sahin Aysegul A, Gonzalez-Angulo Ana Maria, Lluch Ana, Rameh Lucia E, Jacks Tyler, Root David E, Lander Eric S, Mills Gordon B, Hahn William C, Sellers William R, Garraway Levi A

Abstract excerpt

Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through activation of the AKT/PKB kinase. However, here we show through phosphoprotein profiling and functional genomic studies that many PIK3CA mutant cancer cell lines and human breast tumors exhibit...

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Identifiers

PMID: 19573809
DOI: 10.1016/j.ccr.2009.04.012
PMCID: PMC2752826

Genes

PDK1
SGK3
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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