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AKT in cancer: new molecular insights and advances in drug development

27 May 2016

Abstract excerpt

The phosphatidylinositol-3 kinase (PI3K)-AKT pathway is one of the most commonly dysregulated pathways in all of cancer, with somatic mutations, copy number alterations, aberrant epigenetic regulation and increased expression in a number of cancers. The carefully maintained homeostatic balance of cell division and growth on one hand, and programmed cell death on the other, is universally disturbed in...

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PMID: 27232857
DOI: 10.1111/bcp.13021

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