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Article

Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).

International journal of oncology - 1 Mar 2012

Hafsi Sameh, Pezzino Franca Maria, Candido Saverio, Ligresti Giovanni, Spandidos Demetrios A, Soua Zohra, McCubrey James A, Travali Salvatore, Libra Massimo

Abstract excerpt

The most common therapeutic approach for many cancers is chemotherapy. However, many patients relapse after treatment due to the development of chemoresistance. Recently, targeted therapies represent novel approaches to destroy cancer cells. The PI3K/PTEN/AKT pathway is a key signaling pathway involved in the regulation of cell growth. Dysregulated signaling of this...

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Source

Identifiers

PMID: 22200790
DOI: 10.3892/ijo.2011.1312

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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