Article
The PKB/AKT pathway in cancer.
Current pharmaceutical design - 1 Jan 2010
Carnero Amancio
Abstract excerpt
PKB/AKT constitutes an important pathway that regulates the signaling of multiple essential biological processes. PTEN is a dual protein/lipid phosphatase whose main substrate is phosphatidyl-inositol,3,4,5 triphosphate (PIP3), the product of PI3K. Increases in PIP3 result in the recruitment of PDK1 and AKT to the membrane where they are activated. Furthermore, PI3K can be activated by direct binding to oncogenic...
Topics
- Animals
- Antineoplastic Agents
- Enzyme Activation
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Humans
- Mutation
- Neoplasms
- PTEN Phosphohydrolase
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins c-akt