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Signalling specificity in the Akt pathway in breast cancer

18 Sept 2014

Abstract excerpt

Aberrant activation of fundamental cellular processes, such as proliferation, migration and survival, underlies the development of numerous human pathophysiologies, including cancer. One of the most frequently hyperactivated pathways in cancer is the phosphoinositide 3-kinase (PI3K)/Akt signalling cascade. Three isoforms of the serine/threonine protein kinase Akt (Akt1, Akt2 and Akt3) function to regulate cell...

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PMID: 25233414
DOI: 10.1042/bst20140160

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