Article
AKT isoform-specific expression and activation across cancer lineages.
BMC cancer - 16 Jul 2018
Wang Jue, Zhao Wei, Guo Huifang, Fang Yong, Stockman Sarah Elizabeth, Bai Shanshan, Ng Patrick Kwok-Shing, Li Yang, Yu Qinghua, Lu Yiling, Jeong Kang Jin, Chen Xiaohua, Gao Meng, Liang Jiyong, Li Wentao, Tian Xingsong, Jonasch Eric, Mills Gordon B, Ding Zhiyong
Abstract excerpt
BACKGROUND: Aberrant AKT activation is prevalent across human cancer lineages, providing an important therapeutic target. AKT comprises three isoforms that mediate critical non-redundant, even opposing functions in cancer pathophysiology. Therefore, targeting specific AKT isoforms in particular cancers may be more effective than pan-AKT inhibition while avoiding disadvantages of pan-AKT inhibition. Currently, AKT...
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