Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2017

Murakami Katsuhiko S, Shin Yeonoh, Turnbough Charles L, Molodtsov Vadim

Abstract excerpt

Reiterative transcription is a noncanonical form of RNA synthesis in which a nucleotide specified by a single base in the DNA template is repetitively added to the nascent transcript. Here we determined the crystal structure of an RNA polymerase, the bacterial enzyme from Thermus thermophilus, engaged in reiterative transcription during transcription initiation at a promoter resembling the pyrG promoter of...

Topics

Bacillus subtilis
Bacterial Proteins
Crystallography, X-Ray
DNA-Directed RNA Polymerases
Escherichia coli
Models, Molecular
Mutation
Poly G
Promoter Regions, Genetic
RNA, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rifampin

Thermus thermophilus

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28652344
DOI: 10.1073/pnas.1702741114
PMCID: PMC5547606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.PMID 28652344Read ↗

A structural model of transcription elongation.Semantic proximity Read ↗

Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase.Semantic proximity Read ↗

Cotranscriptional folding of a riboswitch at nucleotide resolution.Semantic proximity Read ↗

Human RNA polymerase III termination favors decomposition over facilitated recycling.Semantic proximity Read ↗

Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase.Semantic proximity Read ↗

A bridge to transcription by RNA polymerase.Semantic proximity Read ↗

Open complex scrunching before nucleotide addition accounts for the unusual transcription start site of E. coli ribosomal RNA promoters.Semantic proximity Read ↗

Distinct functions of the RNA polymerase σ subunit region 3.2 in RNA priming and promoter escape.Semantic proximity Read ↗

The role of the bacterial RNA polymerase beta subunit flexible flap domain in transcription termination.Semantic proximity Read ↗

The RNA polymerase trigger loop functions in all three phases of the transcription cycle.Semantic proximity Read ↗

Interplay between σ region 3.2 and secondary channel factors during promoter escape by bacterial RNA polymerase.Semantic proximity Read ↗

Mutations in the CRE pocket of bacterial RNA polymerase affect multiple steps of transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.