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Article

Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase.

Science (New York, N.Y.) - 15 Nov 2002

Yin Y Whitney, Steitz Thomas A

Abstract excerpt

To make messenger RNA transcripts, bacteriophage T7 RNA polymerase (T7 RNAP) undergoes a transition from an initiation phase, which only makes short RNA fragments, to a stable elongation phase. We have determined at 2.1 angstrom resolution the crystal structure of a T7 RNAP elongation complex with 30 base pairs of duplex DNA containing a "transcription bubble" interacting with a 17-nucleotide RNA transcript. The...

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Identifiers

PMID: 12242451
DOI: 10.1126/science.1077464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase.PMID 12242451Read ↗

Sequential release of promoter contacts during transcription initiation to elongation transition.Semantic proximity Read ↗

Functional architecture of T7 RNA polymerase transcription complexes.Semantic proximity Read ↗

The transition to an elongation complex by T7 RNA polymerase is a multistep process.Semantic proximity Read ↗

Cross-linking of promoter DNA to T7 RNA polymerase does not prevent formation of a stable elongation complex.Semantic proximity Read ↗

Relaxed rotational and scrunching changes in P266L mutant of T7 RNA polymerase reduce short abortive RNAs while delaying transition into elongation.Semantic proximity Read ↗

A mutant T7 RNA polymerase that is defective in RNA binding and blocked in the early stages of transcription.Semantic proximity Read ↗

Engineering of T7 DNA-dependent RNA polymerase with activity at elevated temperature.Semantic proximity Read ↗

A structural model of transcription elongation.Semantic proximity Read ↗

The role of the bacterial RNA polymerase beta subunit flexible flap domain in transcription termination.Semantic proximity Read ↗

A bridge to transcription by RNA polymerase.Semantic proximity Read ↗

Scanning mutagenesis reveals roles for helix n of the bacteriophage T7 RNA polymerase thumb subdomain in transcription complex stability, pausing, and termination.Semantic proximity Read ↗

X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.Semantic proximity Read ↗

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