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Article

Mutations in the CRE pocket of bacterial RNA polymerase affect multiple steps of transcription.

Nucleic acids research - 13 Jul 2015

Petushkov Ivan, Pupov Danil, Bass Irina, Kulbachinskiy Andrey

Abstract excerpt

During transcription, the catalytic core of RNA polymerase (RNAP) must interact with the DNA template with low-sequence specificity to ensure efficient enzyme translocation and RNA extension. Unexpectedly, recent structural studies of bacterial promoter complexes revealed specific interactions between the nontemplate DNA strand at the downstream edge of the transcription bubble (CRE, core recognition element) and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Identifiers

PMID: 25990734
DOI: 10.1093/nar/gkv504
PMCID: PMC4499132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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