A bridge to transcription by RNA polymerase.

doi:10.1186/jbiol99

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Article

A bridge to transcription by RNA polymerase.

Journal of biology - 2 Dec 2008

Kaplan Craig D, Kornberg Roger D

Abstract excerpt

A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'.

Topics

DNA-Directed RNA Polymerases
Genetic Variation
Transcription, Genetic

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