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Article

A bridge to transcription by RNA polymerase.

Journal of biology - 2 Dec 2008

Kaplan Craig D, Kornberg Roger D

Abstract excerpt

A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'.

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Identifiers

PMID: 19090964
DOI: 10.1186/jbiol99
PMCID: PMC2776398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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