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Article

The RNA polymerase trigger loop functions in all three phases of the transcription cycle.

Nucleic acids research - 1 Aug 2013

Fouqueau Thomas, Zeller Mirijam E, Cheung Alan C, Cramer Patrick, Thomm Michael

Abstract excerpt

The trigger loop (TL) forms a conserved element in the RNA polymerase active centre that functions in the elongation phase of transcription. Here, we show that the TL also functions in transcription initiation and termination. Using recombinant variants of RNA polymerase from Pyrococcus furiosus and a reconstituted transcription system, we demonstrate that the TL is essential for initial RNA synthesis until a...

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PMID: 23737452
DOI: 10.1093/nar/gkt433
PMCID: PMC3737540

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