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Article

Cotranscriptional folding of a riboswitch at nucleotide resolution.

Nature structural & molecular biology - 1 Dec 2016

Watters Kyle E, Strobel Eric J, Yu Angela M, Lis John T, Lucks Julius B

Abstract excerpt

RNAs can begin to fold immediately as they emerge from RNA polymerase. During cotranscriptional folding, interactions between nascent RNAs and ligands are able to direct the formation of alternative RNA structures, a feature exploited by noncoding RNAs called riboswitches to make gene-regulatory decisions. Despite their importance, cotranscriptional folding pathways have yet to be uncovered with sufficient...

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Identifiers

PMID: 27798597
DOI: 10.1038/nsmb.3316
PMCID: PMC5497173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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