Article
Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells.
Scientific reports - 23 Jun 2017
Ponnuswamy Padmapriya, Joffre Jeremie, Herbin Olivier, Esposito Bruno, Laurans Ludivine, Binder Christoph J, Tedder Thomas F, Zeboudj Lynda, Loyer Xavier, Giraud Andreas, Zhang Yujiao, Tedgui Alain, Mallat Ziad, Ait-Oufella Hafid
Abstract excerpt
Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Baffr deficiency) significantly reduces atherosclerosis in Apoe -/- mice infused with AngII. While...
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