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Article

B Cell–Activating Factor Neutralization Aggravates Atherosclerosis

1 Jun 2018

Abstract excerpt

BACKGROUND: Atherosclerotic cardiovascular disease (heart attacks and strokes) is the major cause of death globally and is caused by the buildup of a plaque in the arterial wall. Genomic data showed that the B cell-activating factor (BAFF) receptor pathway, which is specifically essential for the survival of conventional B lymphocytes (B-2 cells), is a key driver of coronary heart disease. Deletion or...

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PMID: 29858401
DOI: 10.1161/circulationaha.117.032790

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