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Article

Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Howatt Deborah A, Balakrishnan Anju, Moorleghen Jessica J, Muniappan Latha, Rateri Debra L, Uchida Haruhito A, Takano Jiro, Saido Takaomi C, Chishti Athar H, Baud Laurent, Subramanian Venkateswaran

Abstract excerpt

OBJECTIVE: Angiotensin II (AngII) infusion profoundly increases activity of calpains, calcium-dependent neutral cysteine proteases, in mice. Pharmacological inhibition of calpains attenuates AngII-induced aortic medial macrophage accumulation, atherosclerosis, and abdominal aortic aneurysm in mice. However, the precise functional contribution of leukocyte-derived calpains in AngII-induced vascular pathologies has...

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Identifiers

PMID: 26966280
DOI: 10.1161/ATVBAHA.116.307285
PMCID: PMC4850100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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