Article
Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice.
Atherosclerosis - 1 Aug 2010
Uchida Haruhito A, Kristo Fjoralba, Rateri Debra L, Lu Hong, Charnigo Richard, Cassis Lisa A, Daugherty Alan
Abstract excerpt
OBJECTIVE: T and B lymphocytes are associated with atherosclerosis and aneurysms. Angiotensin II (AngII) infusion into hypercholesterolemic mice results in augmentation of atherosclerosis and abdominal aortic aneurysm (AAA) formation. In this study, we determined whether total lymphocyte deficiency reduced AngII-induced vascular diseases. METHODS AND RESULTS: ApoE deficient (apoE -/-) mice were cross-bred with...
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