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Article

AT2R agonist NP-6A4 mitigates aortic stiffness and proteolytic activity in mouse model of aneurysm.

Journal of cellular and molecular medicine - 1 Jul 2020

Sharma Neekun, Belenchia Anthony M, Toedebusch Ryan, Pulakat Lakshmi, Hans Chetan P

Abstract excerpt

Clinical and experimental studies show that angiotensin II (AngII) promotes vascular pathology via activation of AngII type 1 receptors (AT1Rs). We recently reported that NP-6A4, a selective peptide agonist for AngII type 2 receptor (AT2R), exerts protective effects on human vascular cells subjected to serum starvation or doxorubicin exposure. In this study, we investigated whether NP-6A4-induced AT2R activation...

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Share to Angiotensin II
Share to Aorta
Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Osteopontin

Share to Proteolysis

Share to Receptor, Angiotensin, Type 2

Share to Vascular Stiffness

Source

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Identifiers

PMID: 32420690
DOI: 10.1111/jcmm.15342
PMCID: PMC7339180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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